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To determine whether established guidelines that were proposed for use with adult individuals are applicable to children and adolescents. Using a stratified, randomized, two-stage community-based screening, a total of 20 923 untreated individuals underwent Lp(a) and apo(a) screening. We defined large and small apo(a) isoform phenotypes as the 2.5th and 97.5th percentiles of the population distribution in the apo(a) phenotype tertile distribution, respectively. Reference ranges for Lp(a) and apo(a) were established for adults (19-64 years) and children (6-16 years). We identified 659 and 621 subjects in the adult and child age groups, respectively. For adults, Lp(a) and apo(a) reference ranges were 8.2-138 mg/dl and 131-785 mg(2)/dl in men and 11-70 mg/dl and 117-764 mg(2)/dl in women, respectively. For children, Lp(a) and apo(a) reference ranges were 8.3-131 mg/dl and 134-804 mg(2)/dl in boys and 8.6-122 mg/dl and 125-903 mg(2)/dl in girls, respectively. There were no age-related differences in Lp(a) levels among men of the 3 age groups examined (6-14, 15-20, and 21-24 years). Lp(a) levels tended to be lower in younger men than in the older men. Similarly, age did not seem to affect apo(a) levels in either men or women. However, apo(a) levels tended to be higher in younger women. Lp(a) and apo(a) reference ranges established for adults seem to be applicable for children and adolescents, although Lp(a) reference ranges should be interpreted with caution.Pages
Thursday, March 22, 2013
Deal of the Day – The Truth About Vitamins
I
believe that the food the mother makes is the most important factor in the
development of a child. The truth is, however,
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